Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes?

Regulation of Nucleic Acid Sensing Toll-Like Receptors in Systemic Lupus Erythematosus

Toll like Receptor in Infectious Diseases

Many studies reported that genetic variation in interleukin-1 (IL-1) receptors/Toll like receptors (TLRs) are susceptible to infectious diseases. TLRs play an important role in the innate immune response to invading pathogens. TLRs are emerging in conditions such as asthma, rheumatoid arthritis, sepsis syndrome, and systemic lupus erythromatosis, suggesting that targeting of TLRs might be usefu...

A Case of Systemic Lupus Erythematosus with Renal Failure Following the Administration of Sinopharm COVID-19 Vaccine

The outbreak of COVID-19 has been revealed some pathogenic mechanisms which are indicating the role of virus in the pathogenesis of diseases such as diabetes mellitus, autoimmune and cardiovascular diseases. COVID-19 results in deterioration of glycemic control in diabetic patients and even in some cases developed new onset diabetes mellitus which are indicating the possible interfering role of...

Neutrophil extracellular trap-mediated activation of endosomal toll-like receptors induce immune activation in juvenile-onset systemic lupus erythematosus

Introduction Juvenile-onset Systemic Lupus Erythematosus (JSLE) is a multisystem autoimmune disorder characterized by the overproduction of autoantibodies against nuclear selfantigens. Activated neutrophils may undergo cell death by NETosis, forming mesh-like structures termed Neutrophil extracellular traps (NETs). Comprising of DNA, histones and antimicrobial proteins, increasing evidence impl...

ارتباط سطح سرمی تری‌گلیسیرید, لیپو پروتئین با دانسیته‌ی بالا, تومورنکروز فاکتور آلفا و رسپتورهای محلول آن با فعالیت بیماری لوپوس اریتماتوز سیستمیک

Background & Objective: Systemic lupus erythematosus (SLE) is a disease with life-threatening complications. Since evidence indicates that measurement of triglyceride (TG) and HDL levels and tumor necrosis α factor (TNF- α) and its types I and II soluble receptors plays a major role in evaluation of lupus activity, this study was conducted to investigate the relationship between the above menti...